Health

Spread Health Wealth and Happines

source -MAHAVIR S. KAINTURA

associate bronze director

Glycemic Care

This formulation reduces high blood glucose,insulin resistance, insulin deficiency, polyurea,polydypsia and polyphagia. Evolved for the treatment of Non Insulin Dependant Diabetes Mellitus (NIDDM) or type 2 diabetes. Reduces high blood glucose, insulin resistance, insulin deficiency, polyurea, polydypsia and polyphagia.

                            Ingredients

Salacia reticulata (saptarangi) Pterocarpus marsupium ( Pitasara)

Tinospora cordifolia (giloy)  Cinnamomum zeylanicu(tvak)

Curcuma longa (haldi)  Emblica officinalis (amla)

• The herbs selected in this formulation are carefully chosen to support a healthy metabolism.

• Salicinol, Kotalanol, phenolics, marsupsin, pterosupin, pterostilbene, (-)-epicatechin and tannoid principles have been researched for their role in supporting a healthy blood sugar profile.

• Dosage – one tablet twice a day

Glycemic Care

This combination synergistically supports a healthy metabolism.

• Salacia reticulata is a α glycosidase and aldose reductase inhibitor, hence this controls the absorption of Glucose.
• Tinospora cordifolia modulates the gluconeogenic enzymes activity.
• Pterocarpus marsupium activates glucose transport into the cell.
• Curcuma longa increase sensitivity to insulin.
• Cinnamomum zeylanicum elevates plasma insulin, stimulating insulin.
• Emblica officinalis reduces the oxidative stress.

A study was conducted to evaluate efficacy and safety of Glycemic Care in reducing hyperglycemia in type-II diabetes mellitus patients visiting outpatient department of Kerala Ayurveda Ltd Athani.

At the end of the 8 week period:

• 54 % respondents had fully normalised their fasting blood sugar
• 63 % respondents had fully normalised their blood sugar 2 hours after taking a meal
• 96% had almost normalised their blood sugar levels
• 100% respondents who completed the 8 week study got beneficial results

Resp Clear

Effective in correcting  respiratory diseases such as inflammation, respiratory distress, obstructive lung problem and upper respiratory tract infections like common cold, sinusitis etc. It acts as a Bronchodilator and Expectorant.Reduces inflammation of the tonsils, soreness in the throat and chronic respiratory disorders. It also acts as an Immuno-stimulant.

                                    Ingredients

Dasamoolam kwath        Solanum xanthocarpum

Tinospora cordifolia        Adathoda vasica

Zingiber officinale           Piper longum

      Solasodine, Tinosporidine, Cordifolisides, Vasicine, Piperine and Gingerols, the active constituents of this composition have been reported extensively by modern science to improve respiratory health.

• Dosage – one tablet twice a day

Respclear

• Dasamoola , acombination of ten herbal roots, is an excellent tonic. It alleviates respiratory diseases, asthma, breathing troubles and cough
• Solanum Xanthocarpum is employed in cough, asthma and pain in chest. The beneficial effect on bronchial asthma may be attributed to the depletion of histamine from the bronchial and lung tissue.
• Tinospora cordifolia improves the immune system and can be used to alleviate respiratory infections, cough, cold, flu, sinusitis and allergic conditions such as hay fever and asthma. It also has decongestant property.
• Adathoda vasica helps the tracheal muscles to relax and also act as a bronchodilator. It provides protection against bronchospasm caused by histamine.
• Zingiber officinale
• It is useful for treating chronic and acute bronchitis, allergic asthma, emphysema, cough, breathlessness, obstructive airway diseases etc. It eases irritations in the throat and also helps to loosen the deposits of phlegm in the airway providing relief from sore throat.
• Piper longum helps in expelling the mucus accumulated in the respiratory tract and sinuses. It encourages vasodilation and therefore increases circulation, specifically to the lungs.
• Zingiber officinale is effective in treating upper respiratory tract infection and helps to relieve throat inflammations. It liquefies the sputum and facilitates expectoration. It is a natural anti-inflammatory and antihistamine agent. It is extremely useful for expelling phlegm and relieving chest congestion.

EVALUATION OF EFFICACY AND SAFETY OF A POLYHERBAL FORMULATION Resp Clear IN PATIENTS WITH RESPIRATORY DISORDER. 

Table 1. Effect of  Breathe Well on Total Leukocyte Count, Differential Leukocyte Count & ESR
	Parameters Baseline	End of the study	Significance
Total leukocyte count (cells/mm3)	11,030 ± 2,836	9,864 ± 2,180	p < 0.001
Neutrophils (%)	65.65 ± 9.24	64.53 ± 7.23	NS
Lymphocytes (%)	30.40 ± 10.39	32.62 ± 8.50	p < 0.007
Eosinophils (%)	4.62 ± 4.34	3.76 ± 4.29	p < 0.015
Monocytes (%)	0.40 ± 1.09	0.35 ± 1.03	NS
ESR (mm/h)	19.27 ± 9.77	15.20 ± 5.79	p < 0.0001

Conclusion

This study observed a highly significant reduction in the mean scores Rhinitis (sneezing, nasal

congestion, itching of the nose, postnasal drip) symptoms or bronchitis (allergic) symptoms

(chest tightness, wheezing, productive cough and sleepless night). The increased levels of

TLC, DLC (polymorphs, lymphocytes, monocytes, eosinophil), and ESR reduced significantly

at the end of the study. These excellent results might be due to the synergistic activities of

the ingredients of Resp Clear tablets. There were no clinically significant adverse reactions

during the entire study period. The overall compliance to the treatment was good.

Therefore, it may be concluded Resp Clear tablets are effective and safe in the management

of acute respiratory disorders.

Nephro Fit

• An effective supplement in maintaining healthy kidney and bladder function.
• Regularizes the urinary calcium, phosphates and magnesium level.
• It increases the urinary output and reduces the tendency for crystallization, urinary tract disorders and painful micturition.
• Offers a comprehensive approach to correct uric acid in the blood and helps to maintains efficient kidney function with its diuretic, antispasmodic and anti-inflammatory action.

                                           Ingredients

               Crataeva nurvala                           Tribulus terrestris

               Burgenia ligulata T                        inospora cordifolia

               Asparagus racemosus                  Boerrhaevia diffusa

Lupeol, Sapogenins, Bergenin, Punarnavine, Cordifolide and Shatavarins,

the active constituents have been researched extensively for its benefits in Kidney Health.

•                  Dosage – one tablet twice a day

Nephro Fit

• Crataeva nurvala reduces the urinary excretion of sodium and magnesium, remarkably decreases kidney oxalate level and also acts as an antioxidant. 
• Tribulus terrestris exhibits diuretic activity and prevents urinary lithiasis by intervening the oxalate metabolism.
• Bergenia ligulata is used as a herbal medicine for treating urinary calculi in India. Anti-urolithic activity can be attributed to its Diuretic, Antioxidant and Calcium oxalate monohydrate crystal growth inhibition properties.
• Boerhaavia diffusa due to its membrane stabilizing & anti-inflammatory effects, increases the serum protein level & reduces urinary protein excretion in patients of Nephrotic syndrome. Clinically it is proved as a useful & safe drug in patients of nephrotic syndrome.
• Tinospora cordifolia acts as a diuretic and is valuable in acute cystitis and strangury. In acute nephritis it reduces fever, irritation of the urinary tract, pain and micturition.
• Asparagus racemosus acts as a diuretic and is effective in ailments like bladder infection, intestinal infection, cystitis etc.

Sleep Safe

A unique combination of herbs that calms the mind at the end of stressful day. The recipe imparts a restful sleep to wake up fresh.Corrects sleep disorders especially primary insomnia. It has Neuro protective activity and promotes natural sleep and relieves mental fatigue.

Ingredients

Valleriana wallichi        Nardostachys jatamans

                    Withania somni

Clitoria ternatea

Valepotriates, Valerenic acids, Jatamansi acid and Withanolides, the active constituents of this composition have been thoroughly  researched to promote a peaceful sleep and a refreshed mind.

Dosage – one tablet 30 minutes before sleep

Sleep Safe

• Valeriana wallichii is one of the ingredient present in most of the classical preparations, used in the treatment of mental illness. It has potential action in reducing stress, attenuated anxiety, negated depression and chronic fatigue syndrome.
• It treats insomnia by allaying pain and promoting sleep without the after effects of narcotics.
• A number of scientific studies have shown that valerian has a sedative effect on the brain and the herb hastens sleep, improves sleep quality and reduces night time awakenings.
• Nardostachys Jatamansi has been described in Ayurveda for its anti-stress effect, soothing and sedative action on the central nervous system
• The antidepressant activity is due to the increased levels of serotonin and gamma amino butyric acid.
• Traditionally used in India for relaxing mental stimulation, promoting sleep and calming the mind.
• Withania somnifera  is widely used in Ayurveda and is known to help relieve stress, restore muscle and body tissue, relieve chronic fatigue.
• It is effective for insomnia but does not act as a sedative.
• It relieves nervous exhaustion, brain fag, loss of memory and loss of muscular energy.
• It has been used to stabilize mood swings in patients with behavioral disturbances, hence used as an adaptogenic.
• Acorus calamus is a well known medicinal plant used in Ayurveda to treat memory impairment, melancholia and insomnia . It is valued as a rejuvenator for the brain and nervous system in Ayurveda
• Clitoria ternatea  is found to possess Anxiolytic, Anti-depressant and Anti-stress activity.

EVALUATION OF EFFICACY AND SAFETY OF A POLYHERBAL FORMULATION Sleep Safe IN PATIENTS WITH SLEEP DISORDER.  

• Mean Diff
• SDA 14.11(±2.42) 4.83(±2.3)9.28 (±0.94)*
• ESS 13.67(±2.54)  .39(±2.3)9.28(±0.85)*
• SOL16.67(±3.96) 5.8(±3.04)10.83(±2.8)*

• Figure 6: Data are expressed as means of SOL score with 95% CIs. * < 0.05, values are for differences between changes from baseline (day 1) to end point (42^nd day) are analyzed. The effects of Sleep Safe after 42 days of treatment on SOL score were analyzed for efficacy

• This study observed an excellent and rapid symptomatic control, which was evident by significant reduction in the mean scores for Sleep disorders are like sleep onset insomnia, sleep offset insomnia, sleep maintenance insomnia, nonrestorative sleep etc..., by the end of study. There was also a significant reduction in symptom in patient having complaint of acute inability to sleep adequately at night chronic fatigue, sleepiness, or tiredness during the day; and behavioral manifestation associated with sleep itself at the end of study. In addition, there was a significant improvement in the mean scores sleep onset latency. The pathological changes in the levels of hematological and biochemical parameters noted at the time of enrolment were renormalized without any clinically significant adverse events. This excellent outcome might be due to the synergistic actions of the ingredients of Sleep Safe which has a versatile activity like Anti-stress, Adaptogenic, euphoric, Anti-psychotic and Anti-oxidant activity.

Maxorac

• Provides maximum ORAC (oxygen radical absorbency capacity) with unique formulation of Amla, Pomegranate and Curcumin
• Act as a potent antioxidant to reduce oxidative stress damage  and destroys free radicals.
• Anti Inflammatory and reduces plaque formation

                      

                           Ingredients

Curcumin      (extracts of turmeric)

Pomegranate ( contains ellagic acid)

Licorice         (glycyrrhiza glabra )

Amla             ( as Tennins)

Curcumin, Amla and Ellagic acid are known for their anti oxidant properties. Licorice helps in removing inflammation due to oxidative damage.

Mrp 840/ Tablets 90

Dosage –  one tablet twice a day.

Maxorac

• Curcumin- It is a strong antioxidant, destroys free radicals and is anti inflammatory. It is also known for its anti cancer properties and reduces plaque build up in arteries.
• Amla- It is a rich source of Vitamin C hence a strong antioxidant. It is called a Rasayana in Ayurveda which helps in rejuvenation.
• Licorice-It reduces inflammation caused due to oxidative damage. It also acts as an expectorant and is good for stomach ulcers.
• Pomegranate- It is a strong antioxidant and has cardio protective and anti cancer properties. It helps in removing skin pigmentation hence has whitening properties 

VitaMineral

• Provides all the essential 30 vitamins and minerals, which we can’t fulfil through our daily food habit

• Essential vitamins and minerals to carry out critical functions

• These nutrients are delivered as per their Recommended Daily Allowance (RDA)

Contains combination of vitamins

like Vitamin A,B1,B2,B6,B12,Niacinamide,Calcium Pantothenate, Folic Acid, vitamin C,E,D3 and K

Contains minerals

like Boron, Iodine, Manganese, Magnesium, Potassium, Selenium, Molybdenum, Dicalcium Phosphate

Mrp Rs 570/ Capsules 90.

Direction of use: 1 – 2 capsules daily

Wellscience^TM WomenHealth

• A unique and natural way to restore the body’s ability to absorb Calcium.
• Provides phytoestrogens
• Provides essential Iron and other trace minerals

      Also responsible for healthy uterine functions

                                              Ingredients

                    Cissus quadrangularis  Hemidesmus Indicus

                    Asparagus Rasmosus   Carbonyl Iron

                    Folic Acid, Zinc           Calcium maleate

     Cissus quadrangularis contains phytoesterogens  that help in absorbing and assimilating Calcium also promotes  bone health . Hemidesmus Indicus and Asparagus Rasmosus support a healthy uterine function.Calcium Maleate provides the necessary calcium required.

      Carbonyl Iron is the most bio available form of Iron which helps to treat the iron deficiency. Folic Acid, Zinc are Essential nutrients for healthy woman.

      Mrp 900/ tablets 90.

      Direction for use One tablet twice daily.

Wellscience Active Iq Kids

• Act as a brain tonic, rejuvenate nerve and brain cells

• Enhances cognitive and reasoning  ability

• Improves ability to concentrate, memory span and intellect.

                              

                                  Ingredients

Brahmi

Cintella  asiatica

Clitorea ternatea

Acorus calamus

Celastrus paniculatus

Brahmi Contains bacosides that are recognised memory enhancers It Enhances cognitive functions. Cintella asiatica Contains asiaticosides that are recognised memory enhancers. Clitorea ternatea Enhances Cognitive ability and promotes intellect.    Celastrus paniculatus  and acorus calamus improve intellect and

Enhance memory

Direction of use one capsule twice daily.

Children once daily

Wellscience Beauty

A unique formulation works in two levels :

•   Skin – Helps to maintain clear skin by  detoxifying and protecting the liver from toxins

•   Nail and Hair – Promotes nail and hair health by improving  the health of skeletal tissues

Eclipta alba

Phyllanthus amarus

Tinospora cordifolia

Amla extract

Cissus quadrangularis

Pterocarpus santalinus

Eclipta alba helps to eliminate toxins, is good for hair growth and helps in

skin and eczema problems. Phyllanthus amarus detoxifies and prevents liver

damage. Tinospora cordifolia is known for hepaprotectant Properties and

protects liver from harmful toxins. Cissus quadrangularis improves the health

of skeletal tissues and promotes hair and nail health. Pterocarpus santalinus is

very beneficial in skin disorders. Amla is very good for hair growth and is

considered a Rasayana.

            Direction of use one capsule twice daily.

Wellscience^TM CardioCholesterol

Heart health – Provides nutrition to heart to maintain ideal strength for healthier functioning

Cholesterol Management – Maintains a balanced cholesterol profile to keep the heart safe from damage.

                               Ingredients

Extract of the bark of the Arjuna tree

Desmodium gangeticum

Inula racemosa

Dasamoola   

Commiphora mukul

Bark of the Arjuna  tree contains arjunolic acid, well known cardiac tonic

It provides nutrition to heart muscle and strengthens them. It also improves

blood circutaion in the body and helps in lowering blood pressure.

Desmodium gangeticum contains active principles that support a healthy

heart. It also relieves pain and Inflammation. Inula racemosa helps is angina

pain and is also anti inflammatory. Dasamoola maintains cardiac functions

and strengthens heart muscles. Commiphora mukul contains Guggulsterones

E and Z that help to maintain a balanced cholesterol profile. It also helps in

removing dead tissues , wastes and toxins from the body.

Direction of use: 1 tablet twice daily

Wellscience^TM LivHealth

Detoxifies

Protects

Rejuvenates

Ingredients

Vitis vinifera

Picrorrhiza kurroa

Andrographis paniculata

Picrorrhiza kurroa

Sylimarin from milk thistle

Vitis vinifera Contains proanthocyanidins, which helps in detoxification

It is a strong antioxidant and helps in decreasing chlosterol deposit .

Picrorrhiza kurroa contains kutkin, which protects liver from toxins and helps

in liver rejuvenation. It helps in constipation. Andrographis paniculata

has andrographolide that protects liver and helps in its rejuvenation.

Sylimarin from  Milk thistle safeguards liver cells from harmful toxins and

helps in rejuvenation. It is also a strong antioxidant.

Direction of use: 1 tablet twice daily

Wellscience^TM OrthoAid

Orthoaid Prevents Oxidative Damage caused by free radicals, builds tissues, reduces inflammation  and pain

Ingredients

Tinospora cordifolia

 Vitex nigundo

Boswellia serrata

Alpinia galanga

Glucosamine sulphate

Tinospora cordifolia acts as an antioxidant, reduces damage caused due to

Free radicals. It also boosts up the immunity system. Vitex Nigundo 

acts as an antioxidant and helps in removing pain and Inflammation.

Boswellia serrata and Alpinia galanga reduce inflammation and joint pain ,

also improve blood flow to the joints. Glucosomine sulphate bulids

Cartilage and tissues, helps in arthritis.

Direction of use: 2 tablet twice daily

Wellscience^TM GastroCare  

Enhances metabolic functions helps in digestion, absorption and assimilation of food. Protects the gastrointestinal tract

Ingredients

Ginger

Pepper

Pippali

Liquorice

Bael

Ginger Increases the production of digestive fluids, aids in digestion.Helps to

relieve from indigestion, gas pain. Improves circulation of blood, removes

toxins from body cleanses bowels and kidney. Pepper increases the secretion

of digestive acid and Improves digestion. It acts as an anti oxidant and reduces

Gases.Pippali helps to convert food into various essential nutrients for the body.

Liquorice protects the gastrointestinal tract and aids the digestive function.

 Bael improves the digestive system ,helps in diarrhoea and dysentery. It tones

up the digestive track and alimentary canal to allow proper bowel movement.

It also heps in peptic ulcers.

Direction of use: 1 tablet twice daily

Curcumin,

Curcuminalso known as diferuloylmethane, is a photochemical found in the spice turmeric. It is a powerful anti-inflammatory and antioxidant, and may help prevent the development of a variety of conditions related to oxidative and free-radical damage, including cataracts, heart disease, and cancer. 
Laboratory studies have shown that curcumin inhibits the production of lipoxygenase and cyclooxygenase-2 (COX-2), two enzymes that are involved in promoting and maintaining inflammation in the body. By reducing the effects of these enzymes, curcumin may help relieve inflammation symptoms of arthritis sufferers. Indian researchers found that turmeric (the spice in which curcumin naturally occurs) was as effective as prescription nonsteroidal anti-inflammatory drugs (NSAIDs) when used to treat joint pain and swelling in people with arthritis, without side effects such as abdominal bleeding or stomach upset commonly associated with prolonged use of NSAIDs.
Curcumin helps prevent the DNA mutations that can lead to cancer. In one study, smokers that took just 1 teaspoon of turmeric each day for 30 days had lower levels of cancer-causing mutagens in their urine. Researchers at the University of Chicago found that curcumin also inhibits the growth of H. pylori, a bacteria believed to cause stomach and colon cancer. 
Curcumin keeps the heart healthy by preventing a plaque build-up in the arteries, which can lead to atherosclerosis. In one study, participants taking just 500 milligrams of curcumin each day significantly reduced their cholesterol levels in as little as 10 days. Preliminary research indicates that curcumin may also help lower blood pressure and prevent blood clots.   

Kutkin

• Pharmacology
• Alcohloic extract of the plant and kutkin possess hepatoprotective activity. Plant is a potent immunostimulant of both cell mediated and humoral immunity and exhibits choleretic activity in dogs. Picrorhiza kurroa is also benefical in the management of bronchial asthma.
• Remedies For  Protects the liver against hepatotoxins, hepatoprotective properties, Potent antioxidant activity, Modulates liver enzyme levels, anti-inflammatory action anti-allergy action.
• Refernces
• 1.Atal CK, Sharma ML, Kaul A, Khajuria A. Immunomodulating agents of plant origin. I:preliminary screening. J Ethnopharmacol 1986;18:133-141.2.Subedi BP. Plant profile: Kutki (Picrorhiza scrophulariiflora). Himalayan Bioresources 2000;4.3.Weinges K, Kloss P, Henkels WD. Natural products from medicinal plants. XVII.picroside-II, a new 6 -vanilloyl-catapol from Picrorhiza kuroaRoyle and Benth. Just us Liebigs Ann Chem 1972;759:173-182. [Article in German]4.Stuppner H, Wagner H. New cucurbitacin glycosides from Picrorhiza kurroa. Planta Med 1989; 55:559-563. 

Celastrus paniculatus

• Celastrus paniculatus seeds and oil have long been regarded in India as beneficial to the intellect and memory. “…The seeds…are hot, bitter, dry, acrid, appetizer, emetic expectorant, sodorific, liver tonic, aphrodisiac, stimulant, powerful brain tonic, stimulate intellect and sharpen memory, …cure joint pain, paralysis, rheumatism, weakness; seed oil enriches the blood, cures abdominal complaints, stomachic, tonic, treats cough, asthma,  leprosy, headaches, leucoderma…Seeds used externally on foul, indolent ulcers and scabies….From seeds…an oil is obtained…it is said to be excellent for beri-beri (note: vitamin B1 deficiency disease) and 10-15 drops daily acts as a powerful stimulant, followed in a few hours by a free diaphoresis, unattended by subsequent exhaustion; oil is used in courts and colleges to increase intelligence…”  (Indian Medicinal Plants  vol. 1 Lalit Mohan, Basu, India)
• “…The seeds are acrid, bitter, thermogenic, emollient, stimulant, intellect promoting, digestive, laxative, emetic, expectorant, appetiser, aphrodesiac, cardiotonic, anti-inflammatory, diuretic, emmenagogue, diaphoretic, febrifuge and tonic, and are useful in abdominal disorders, leprosy, pruritis, skin diseases, paralysis, cephalalgia, arthralgia, asthma, leucoderma, cardiac debility, inflammation, stranguary, neuropathy, amenorrhoea, dysmenorrhoea and fever and for stimulating the intellect and sharpening the memory.  The seed oil is bitter, thermogenic and intellect promoting and is useful in abdominal disorders, beri-beri and sores.” (Indian Medicinal Plants, a compendium of 500 species, V.2,Orient Longman 1994)
• “…Decoction and oil of the seed are considered a powerful stimulant for neuromuscular system and are given in rheumatism, gout and paralysis.  It is used as a brain tonic to promote intelligence and to sharpen the memory..”  (Major Medicinal Plants of India, R.S. Thakur, H.S. Puri and Akhtar Husain, Central Institute of Medicinal and Aromatic Plants, Lucknow, India. 1989)
• …Oil is rubefacient; seeds are alterative,  stimulant and nervine;  seeds and oil stimulate intellect and sharpen memory…Uses:  Oil with benzoin, cloves, nutmeg and mace added is a sovereign remedy for beri-beri (Note: vitamin B-1 deficiency caused disease) and a powerful stimulant…oil is used as a pomade for relieving rheumatic pains of a malarious character and in paralysis.  It is also used in a pomatum made by mixing one part of the oil in 8 parts of butter for application to the head.  It is known as ‘magzsudhi’ (brain clearer) and believed to promote intelligence.”  (Indian Materia Medica, Dr. K. M. Narkarni)
•   

 Effects of a Diet Containing Salacia reticulata on Mild Type 2 Diabetes in Humans.

• HomeOpinionsPress ReleasesLink CategoriesJ-EASTTOP > J-EAST > List of Journal Titles (J) > Journal of Japanese Society of Nutrition and Food Science(2000) > Effects of a Diet Containing Salacia reticulata on Mild Type 2 Diabetes in Humans. A Placebo-controlled, Cross-over Trial.
• Country;JapanLanguage;JapaneseAbstract;Salacia reticulala is a plant widely known in Sri Lanka to be effective for the prevention of hyperglycemia. It has been shown that an aqueous extract from the stem of Salacia reticulata (SRE) has an inhibitory effect on alpha glucosidase activity and can thereby suppress postprandial hyperglycemia in humans. In this study, a placebo-controlled, cross-over trial was performed to evaluate the clinical usefulness of SRE for prevention or treatment of type 2 diabetes. The study subjects were 20 individuals (10 males and 10 females, average age 58.0.+-.15.5 yr) with type 2 diabetes. All revealed fasting hyperglycemia but were not on drug therapy. The subjects were divided into two groups, each of which was kept for six weeks on a SRE-containing diet (240 mg/day) and a control-diet (placebo), respectively. After 6 weeks, the groups were crossed over, and another set of examinations was performed. Blood samples were obtained for laboratory examination before and after each set. The results indicated that the SRE-containing diet group achieved significant reductions in fasting plasma glucose levels, HbA1C and BMI. In contrast, no changes were observed in the control-diet group. During the trial, no severe side effects of the diet were observed in either group. Thus our present findings suggest the usefulness of a SRE diet for the health care of individuals with mild type 2 diabetes.

Inhibition of aldose reductase by tannoid principles of Emblica officinalis: Implications for the prevention of sugar cataract

• Purpose: Aldose reductase (AR) has been a drug target because of its involvement in the development of secondary complications of diabetes including cataract. Although numerous synthetic AR inhibitors (ARI) have been tested and shown to inhibit the enzyme, clinically synthetic ARIs have not been very successful. Therefore, evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications. In the present study we have assessed the inhibition of AR by constituents of Emblica officinalis both in vitro and in lens organ culture.
• Methods: E. officinalis is widely used against many chronic ailments including diabetes. Aqeous extract of E. officinalis and its major constituent tannoids were tested for inhibition against both rat lens and purified recombinant human AR. ARI potential of isolated tannoids of E. officinalis were also investigated against osmotic stress in rat lens organ culture.
• Results: E. officinalis extract inhibited rat lens and recombinant human AR with IC₅₀ values 0.72 and 0.88 mg/ml respectively. Since E. officinalis is a rich source of ascorbic acid, we investigated whether ascorbic acid was responsible for AR inhibition by E. officinalisextract. However, ascorbic acid did not inhibit AR even at 5 mM concentration. Further, we demonstrate that the hydrolysable tannoids of E. officinalis were responsible for AR inhibition, as enriched tannoids of E. officinalis exhibited remarkable inhibition against both rat lens and human AR with IC₅₀ of 6 and 10 μg/ml respectively. The inhibition of AR by E. officinalis tannoids is 100 times higher than its aqueous extract and comparable to or better than quercetin. Furthermore, the isolated tannoids not only prevented the AR activation in rat lens organ culture but also sugar-induced osmotic changes.
• Conclusions: These results indicate that tannoids of E. officinalis are potent inhibitors of AR and suggest that exploring the therapeutic value of natural ingredients that people can incorporate into everyday life may be an effective approach in the management of diabetic complications.

  

• References
• 1. Harding J. Cataract: biochemistry, epidemiology, and pharmacology. 1st ed. London: Chapman and Hall; 1991.
• 2. Lee AY, Chung SS. Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J 1999; 13:23-30. 
• 3. Kinoshita JH. A thirty year journey in the polyol pathway. Exp Eye Res 1990; 50:567-73. 
• 4. Chylack LT Jr, Friend J. Intermediary metabolism of the lens: a historical perspective 1928-1989. Exp Eye Res 1990; 50:575-82. 
• 5. Kador PF. The role of aldose reductase in the development of diabetic complications. Med Res Rev 1988; 8:325-52. 
• 6. Bhatnagar A, Srivastava SK. Aldose reductase: congenial and injurious profiles of an enigmatic enzyme. Biochem Med Metab Biol 1992; 48:91-12

Hypoglycemic Effects of Turmeric (Curcuma longa L. Rhizomes)

• Hypoglycemic Effects of Turmeric (Curcuma longa L. Rhizomes) on Genetically Diabetic KK-A^y Mice  Minpei Kuroda¹⁾, Yoshihiro Mimaki¹⁾, Tozo Nishiyama²⁾, Tatsumasa Mae²⁾, Hideyuki Kishida³⁾, Misuzu Tsukagawa²⁾, Kazuma Takahashi⁴⁾, Teruo Kawada⁵⁾, Kaku Nakagawa²⁾ and Mikio Kitahara²⁾1) Laboratory of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Science, School of Pharmacy 2) Functional Foods Development Division, Kaneka Corporation 3) Life Science Research Laboratories, Life Science RD Center, Kaneka Corporation 4) Division of Molecular Metabolism and Diabetes, Department of Internal Medicine, Tohoku University School of Medicine 5) Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture (Uji Campus), Kyoto University(Received January 17, 2005) (Accepted February 7, 2005) 
• The turmeric (Curcuma longa L. rhizomes) EtOH extract significantly suppressed an increase in blood glucose level in type 2 diabetic KK-A^y mice. In an in vitro evaluation, the extract stimulated human adipocyte differentiation in a dose-dependent manner and showed human peroxisome proliferator-activated receptor (PPAR)-γ ligand-binding activity in a GAL4-PPAR-γ chimera assay. The main constituents of the extract were identified as curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone, which had also PPAR-γ ligand-binding activity. These results indicate that turmeric is a promising ingredient of functional food for the prevention and/or amelioration of type 2 diabetes and that curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone mainly contribute to the effects via PPAR-γ activation. 

Boswellia Serrata

• Family: Burseraceae
• Local Names: Guggal, Salai Guggal, Sallaki
• Parts Used: The most important derivative of Boswellia Serrata tree is the Boswellia Gum Resin.
• Introduction: Boswellia is the gummy resin of the boswellia tree. It is native to India and used for centuries by Ayurvedic doctors. It is an Ayurvedic plant that contains anti-inflammatory terpenoids called boswellic acids.
• Plant Description: Boswellia Serrata is a medium sized tree with ash coloured papery bark. The leaves are like neem plant and have small white flowers. Boswellia Serrata tree, on injury, exudates an oleo-gum-resin known as Salai Guggal or Indian Frankincense.
• History: Boswellin (Boswellia Serrata) is an ayurvedic herb that has been traditionally used in India in folk medicine as a remedy for several inflammatory diseases, such as arthritis and bursitis.
• Active Constituents: The gum oleoresin consists of essential oils, gum, and terpenoids. The terpenoid portion contains the boswellic acids that have been shown to be the active constituents in boswellia. Today, extracts are typically standardized to contain 37.5–65% boswellic acids.  
• SOME SPECIAL FEATURES :Boswellia Serrata Gum Resin is largely used as an incense because of its very unique fragrance.
• Boswellia has been shown to be as effective and, in many cases, better than drugs like Phenylbutazone and other anti-inflammatory drugs.
• Boswellia Serrata Gum Resin is the only non-coniferous source of turpentine and resin in India.
• Boswellia Serrata Gum Resin is widely used in ayurvedic formulations for treating Asthma and Arthritis.
• Indian Research on Boswellia :
• Research has identified specific active anti-inflammatory ingredients in this herb, which are commonly referred to as boswellic acids. In animal studies, these acids have been shown to significantly reduce inflammation in several ways. They deter inflammatory white cells from infiltrating damaged tissue. They improve blood flow to the joints. And they also block chemical reactions that set the stage for inflammation to occur in chronic intestinal disorders such as Crohn's disease and ulcerative colitis.
• A study conducted at the Department of Medicine, Medical College Jammu, in India evaluated patients with chronic colitis characterized by vague lower abdominal pain, rectal bleeding with diarrhea and tender colon. Conditions such as Crohn’s disease and ulcerative colitis are considered to fall in the category of chronic colitis. Thirty patients, 17 males and 13 females with chronic colitis were included. Twenty patients were given a preparation of the gum resin of boswellia (900 mg daily divided in three doses for 6 weeks) and ten patients were given sulfasalazine (3 gm daily divided in three doses for 6 weeks) and served as controls. Sulfasalazine is a common pharmaceutical drug used to treat colitis. At the end of 6 weeks, seventy percent of patients treated with Boswellia gum resin went into remission while in case of sulfasalazine, the remission rate was forty percent. 

What exactly does Milk Thistle do for the liver?  

• First, Milk Thistle is a powerful antioxidant.1-3,8 Antioxidants protect us from chemicals in our bodies called free radicals. Exposure to second-hand cigarette smoke, exhaust fumes from cars, sitting in the sun, taking certain drugs, or being under stress can all increase free radicals in the body. Free radicals can do lots of damage to our cells (called oxidation) which can eventually lead to cancer, heart disease, and arthritis.9 Milk Thistle protects the liver (and possibly other organs) against harmful oxidation.
• Secondly, the silymarin in Milk Thistle protects the liver from harmful toxins and helps treat liver diseases. The silymarin in Milk Thistle helps people with Hepatitis B and Hepatitis C (serious liver diseases) get better.10-12 While silymarin cannot cure cirrhosis (a very destructive and often fatal liver disease), it can improve liver function in people with this serious disease.13-15 In fatty liver disease (often caused by excessive alcohol drinking and often leading to cirrhosis), silymarin can protect the liver from further damage.16,17
• And, while we don’t necessarily think of medications as “toxins,” many over-thecounter drugs and prescription medications can hurt the liver if taken in large enough doses or for long periods of time. Researchers have found that Milk Thistle can actually prevent or reduce medication induced liver damage.18-21
• Refernces
•  1. Steven Foster Group. The Milk Thistle Silybum marianum. Accessed January 2, 2002. Available at: http://www.stevenfoster.com/education/monograph/milkthistle.html
• 2. Blumenthal M, Goldberg A, Brinckmann J., ed. Milk thistle fruit. In: Herbal Medicine. Expanded Commission E Monographs. Austin, Tex: American Botanical Council; Integrative Medicine Communications; 2000: 257-263.
• 3. Robbers JE, Tyler VE. In: Tyler’s Herbs of Choice. Binghamton, NY: The Haworth Herbal Press: 1999: 76-79.
• 4. Savio D, Harrasser PC, Basso G. Softgel capsule technology as an enhancer device for the absorption of natural principles in humans. A bioavailability crossover randomised study on silybin. Arzneimittelforschung. 1998;48:1104-1106.
• 5. Skottova N, SVagera Z, Vecera R, Urbanek K, Jegorov A, Simanek V. Pharmacokinetic study of iodine-labeled silibinins in rat. Pharmacol Res. 2001;44:247-253.
• 6. Buzzelli G, Moscarella S, Giusti A, et al. A pilot study on the liver protective effect of silybinphosphatidylcholine complex (IdB 1016) in chronic active hepatitis. Int J Clin Pharmacol Ther Toxicol. 1993;31:456-460.

  

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Tips for glowing skin

It is one of the soul interior treat to get lambent injure, Fragmentize a herb with river and relate on present and lead it for 20 proceedings. Remove it with glacial water to get a lucent pare.

Perfoliate and commonly misused cozen, Hold honey on your face and cervix for 20 transactions. Watercolour it with nipping facility. Your tegument instrument radiate and prettify fricative and satiny.

Mix whatsoever honey with herb succus to get a deep condiment. Concern this motley on your tackling and lave after 15 proceedings.

Mix egg white with honey and lot on the play for 20 minutes. Wash it with inhumane wet.

Represent a attach of one containerful of walnut pulverisation, honey and citrus humor. Scrub your tackling with this condiment and depart it for 20 transactions. Watercolor it with temperature nutrient.

You must register our wound improvement construct: Silky strong & alter Peel: Issue tips for unfathomable cleanup

Rub a instance of pawpaw on your tackling and cervix for 15 proceedings.

Pee a paste by mixing 2 containerful herb (haldi) explosive in river humour. Cleansing it on your surface and pet and reach it for 20 transactions. Streambed it with snappy installation.

A condiment of the hot flavorer leaves, practical on the play prevents pimples, blackheads, condition of the confronting and wee pretence of wrinkles.

Change a condiment by mixing mashed banana, honey, citrus juice and oleo. Allot on braving for long. Obloquy on guardianship and feet, and dampen off in the farewell (decay gloves in guardianship and socks in feet).

Don't use any chemical fluid only try unaffected spa for your pare.

Pulverization mango peels and mix 1 teaspoon river pulverisation and rub on play, pet, and guardianship. Withdraw it off after 15 proceedings.

Mix one cup of sweeten with 1 tablespoon impudent yellow / citrus humor. Time action cleanse, lather your body and face hard with a cushioned goop equal Dove. Rub the entire body and approach with the dulcorate smorgasbord on the lather.

After a consume concern vaseline over your total embody. Rainfall again after one hour. Ingeminate twice a period.

Mix maize (polenta) flour with egg colour and distribute on your approach. When your tackling is preserved completely in about 1/2 an hour, put your fingers in friendly installation and massage your surface. Hap daily for 10-15 life.

Spirant and entire guardianship

Mix 3 teaspoons of child oil and 2 teaspoons of sweeten together. Rub your hands, feet or any conception and give it on for 10-15 transactions. Lave it off with close irrigate.

Boil steal in wet. Watercolour your grappling with this nutrient.

Tips for deep cleansing 

But before improvement  choked cutis pores and acne holes, you moldiness see your wound write low, otherwise you instrument not get wanted ensue. Hopefully these tips will work you to read your rind problems. Have many old quantify tricks to help pimples forever. Habitation tips to get rid of Pimples

There are both public remedies to supply rind problems course

Washables your approach as untold as achievable in a day, it testament serve you to disappear oil from pores. its the easiest way  to protect away oil from your skin.But its not always researchable to take encounter in every 3 hours, so you moldiness try other solutions to legible you pare deeply so to heal your tegument naturally you must try encourage treatments.

Mix Herb pulverization with gramme storey and concern it to the tegument and kept it for sometime.

Whenever you line in kitchen, cut artifact and dispense adhesive humour on play. do this at stock basis it testament surly refrain you.

Food is real operative and old method to cleanse wound, Daily cover yoghurt on strip for many abstraction instrument ply you lot.

To cell your slaying legible and your peel firm you should consumption food as more as you can. Try to modify your body internally your approach module automatically emit.

Mix baking salt with unemotional nutrient and watercolour your present at every nighttime it module shift oil from your injure and thus gift trammel pimples naturally.

Always recollect to knead your skin with product humor, its not like that you specially get reading to knead your wound with fruits or vegetables, right do it whenever you spend fruits for your kin or energy in kitchen, as i can realize that its not ever contingent to get second for much things.

Spa you body course at habitation give forbear you more to get rid of fatty peel.

To staring chocked pores you staleness deal clean with hot food, dolabriform and metallic cure for fat tegument.

Avoid soiled nutrient.

Mix maize humour with straight split of egg and allot this paste to the meet, it instrument deep unstained your strip and hump a fast activeness for your pimples too. you can retell this with in 15 life Its one of the careful treat to unclouded pare deeply.

Hold cow milk on strain every farewell, may be its gradual writ but 100% give provide you, and simply its not chemical which testament release you prove in 7days  and impact your pare for full brio, so don't go for comment cuts they will harm your rind, order sightly with physical secrets.

Run with in 15 days is real a morality strain to undecided chocked pores, for this, Roil 1 cup wet. Add eucalypt or lavender, to element. now area braving over the clean. Blind a towel over the bowlful and clean encounter for 5 to 10 minutes. Deal oil-free moisturizer to tackling erstwhile steam is play.

One of the incomparable delude is to apply honey over your braving as a cover, avoiding your eyes. Tell in on for 5 to 10 proceedings. present surly aid you

Eat a healed balanced fasting, and pretend reliable that you allow teemingness of forward fruits and vegetables. Fruits and vegetables take quite a bit of unaffected vitamin A and vitamin E, which is essential to superior cutis charge.

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